MicroCC-25 Plus Advanced Hematology Analyzer

MicroCC-25 Plus Advanced Hematology Analyzer

PRIMARY CLINICAL & DIAGNOSTIC USES

1. Five-Part Differential for Comprehensive Leukocyte Analysis

• Primary Use: Provides a fully automated, 5-part differential (5-diff) hematology analyzer that measures 25 parameters including WBC and the five leukocyte subpopulations: lymphocytes (LYM), monocytes (MON), neutrophils (NEU), eosinophils (EOS), and basophils (BAS), with both absolute counts and percentages . The system also reports 4 research parameters: atypical lymphocytes (ALY#, ALY%) and immature granulocytes (IG#, IG%) .

• How it helps: For the hematologist and infectious disease specialist, the 5-part differential enables precise characterization of leukocyte responses—distinguishing bacterial infections (neutrophilia), viral infections (lymphocytosis or lymphopenia), parasitic infections (eosinophilia), allergic conditions (eosinophilia, basophilia), and hematologic malignancies (monocytosis, blast detection). For the patient with fever, suspected sepsis, or undergoing chemotherapy, the complete differential helps clinicians distinguish between infection types, monitor bone marrow function, detect early signs of leukemia, and guide appropriate antimicrobial or immunosuppressive therapy.

2. Complete Erythrocyte Analysis for Anemia and Red Cell Disorders

• Primary Use: Measures comprehensive RBC parameters including RBC count, hemoglobin (HGB), hematocrit (HCT), MCV, MCH, MCHC, RDW-CV, and RDW-SD using impedance aperture technology (80µm ruby aperture) and photometric hemoglobin measurement at 550nm wavelength .

• How it helps: For the hematologist and pathologist, the detailed RBC indices enable accurate classification of anemias—microcytic (iron deficiency, thalassemia), normocytic (anemia of chronic disease, acute blood loss), and macrocytic (B12/folate deficiency). For the patient with fatigue, pallor, or known chronic disease, precise RBC parameters guide diagnosis of iron deficiency anemia, hemolytic anemia, bone marrow disorders, and chronic disease anemia, enabling appropriate treatment with iron supplementation, vitamin B12/folate, erythropoiesis-stimulating agents, or transfusion.

3. Platelet Analysis for Thrombocytopenia and Bleeding Disorders

• Primary Use: Measures platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet-large cell ratio (P-LCR), and platelet-large cell count (P-LCC) for comprehensive thrombocyte assessment .

• How it helps: For the hematologist and oncologist, the detailed platelet parameters are essential for diagnosing thrombocytopenia (low platelets due to immune destruction, chemotherapy, or bone marrow failure), thrombocytosis (high platelets due to reactive conditions or myeloproliferative neoplasms), and platelet function disorders. For the patient with unexplained bruising, petechiae, or bleeding tendencies, accurate platelet assessment guides diagnosis of immune thrombocytopenia (ITP), chemotherapy-induced myelosuppression, disseminated intravascular coagulation (DIC), and essential thrombocythemia, enabling timely treatment to prevent hemorrhagic or thrombotic complications.

4. Automated Reporting with Histogram and Scattergram Analysis

• Primary Use: Generates WBC, RBC, and PLT histograms plus 5-diff scattergrams for visual analysis of cell population distribution and abnormal cell detection; internal memory stores 100,000 patient results with full histograms . The system uses laser flow cytometry for 5-diff analysis, electrical impedance for RBC/PLT counts, and colorimetry for hemoglobin measurement .

• How it helps: For the clinical pathologist and laboratory supervisor, the histogram displays and 5-diff scattergrams enable real-time monitoring of cell population abnormalities, flagging of atypical results, and detection of abnormal populations such as blasts, atypical lymphocytes, and immature granulocytes. For the patient with suspected leukemia, myelodysplastic syndrome, or atypical lymphoid proliferations, histogram and scattergram abnormalities prompt manual slide review, ensuring detection of abnormal cell populations that may indicate serious hematologic disease.

SECONDARY & SUPPORTIVE USES

1. Pediatric and Neonatal Hematology Testing: Requires only 15 µL of whole blood (20 µL pre-diluted capillary) for complete analysis, enabling blood collection from neonates, infants, and small children with minimal phlebotomy volume and reduced patient discomfort .

2. Pre-Diluted Sample Mode for Capillary Blood: Accepts 20 µL pre-diluted samples, ideal for finger-stick capillary blood collection in outpatient clinics, pediatric wards, and geriatric patients with difficult venous access .

3. Pre-Operative Surgical Clearance: Provides rapid CBC and 5-diff results for pre-anesthesia risk assessment and surgical clearance, detecting occult anemia, thrombocytopenia, leukocytosis, or left shift before elective procedures.

4. Chemotherapy and Radiation Therapy Monitoring: Tracks serial blood counts in oncology patients undergoing myelosuppressive therapy, enabling dose adjustment and supportive care interventions (growth factors, transfusions) .

5. Infectious Disease Diagnosis and Monitoring: Supports diagnosis of bacterial sepsis (neutrophilia, left shift with IGs), viral infections (lymphocytosis or lymphopenia), parasitic infections (eosinophilia), and monitoring of treatment response .

6. Chronic Kidney Disease (CKD) Anemia Management: Monitors hemoglobin, RBC, and RDW parameters in dialysis patients for erythropoiesis-stimulating agent (ESA) dosing and anemia management.

7. Inflammatory and Autoimmune Disease Assessment: Tracks WBC parameters and platelet counts in patients with rheumatoid arthritis, lupus, and inflammatory bowel disease to assess disease activity.

8. Pre-Employment and Occupational Health Screening: Performs baseline CBCs for workers in chemical, mining, and manufacturing industries to monitor for hematologic toxin exposure.

9. Sports Medicine and Athlete Monitoring: Assesses hemoglobin and hematocrit levels in athletes for anemia screening, endurance performance evaluation, and anti-doping compliance.

10. Clinical Research and Drug Trials: Provides standardized hematologic endpoint measurement for Phase I-IV clinical trials, including safety monitoring for drug-induced cytopenias.

11. Blood Bank and Donor Screening: Supports donor hemoglobin screening for eligibility, ensuring donor safety and blood product quality.

12. Mass Casualty and Disaster Response: 60-test-per-hour throughput enables efficient processing of large patient volumes during emergency department surges and mass casualty events .

13. Public Health Screening Programs: Supports community-based anemia screening, thalassemia carrier detection, and hematologic health surveillance in resource-limited settings.

14. HIV/AIDS Disease Progression Monitoring: Monitors lymphocyte counts and hemoglobin levels in HIV patients as indicators of immune status and antiretroviral therapy effectiveness.

15. LIS Integration and Electronic Medical Records: Bi-directional LIS connectivity supports HL7 communication, sample tracking, and integration with hospital information systems; connectivity options include USB x4, RJ-45 Ethernet, and external barcode reader .

16. QC Program with Levey-Jennings and X-B/X-R Charting: Built-in quality control with 60 QC files x 500 results, mean/SD/CV% calculation, Levey-Jennings charts from 500 results, X-B with 100 QC data points (20-200 sample groups), and X-R with 60 groups (500 results per group) for comprehensive laboratory quality assurance .

17. Multi-Language Support for International Deployment: Available languages include English, Spanish, Russian, French, and Ukrainian, with Windows-based operating system and 10.4-inch color touchscreen with virtual keyboard and user profiles with access level restrictions .

18. External Peripherals Support: Supports connection of external printer, mouse, keyboard, and barcode reader via multiple USB ports (4x) and RJ-45 Ethernet for expanded functionality and LIS integration .

19. Automatic Maintenance with Real-Time Alerts: Features real-time messages, automatic maintenance scheduling, optional alerts for critical conditions, and reagent level monitoring for uninterrupted operation .

20. RFID Reagent Identification: Identifies reagents after reading a special RFID tag, ensuring correct reagent lot tracking and quality control compliance .