Electronic Titrator (dTrite-Pro)

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The Electronic Titrator (dTrite-Pro) is a fully electronic, digitally controlled bottle-top titration system engineered to completely replace traditional manual glass burettes. Leveraging a precision electronic drive system and a high-accuracy metering pump, it automates the titration workflow, eliminating the inherent subjectivity and variability of manual methods related to drop control, color perception, and human error. The instrument achieves exceptional volumetric precision, with a minimum single-drop volume of 10 μL (10mL model) or 20 μL (25mL and 50mL models), and is fully compliant with ISO 8655 standards. It supports all major titration types: acid-base, redox, precipitation, and complexometric.
For the pharmaceutical QC, environmental, and food safety analyst, the dTrite-Pro provides a significant leap in accuracy, efficiency, and data integrity. Available in three cylinder sizes (10mL, 25mL, 50mL), it features a 4.3-inch TFT color touchscreen for intuitive method control, a detachable remote panel for safe distance operation, and a built-in 3500mAh rechargeable battery for hours of cord-free use. It also features Bluetooth and WiFi connectivity for seamless integration with PCs and LIMS, enabling paperless data management and GLP/GMP compliance.
For the patient and the public, the use of the dTrite-Pro in QC and testing laboratories directly translates to safer, higher-quality pharmaceuticals, a more rigorously monitored and protected public water supply, and safer food products. By providing accurate, traceable data, it helps ensure that the products that reach consumers are safe, effective, and of consistent, high quality.
Description

Electronic Titrator (dTrite-Pro)

PRIMARY CLINICAL & DIAGNOSTIC USES

1. Pharmaceutical Quality Control and Drug Content Determination
  • Primary Use: Provides a fully electronic, digitally controlled bottle-top titration system for precise quantitative analysis of active pharmaceutical ingredients (APIs), excipients, and finished drug products, performing acid-base, redox, precipitation, and complexometric titrations with high accuracy.
  • How it helps: For the pharmaceutical QC chemist and analyst, the dTrite-Pro eliminates subjective errors and manual inconsistencies inherent in traditional glass burettes. Its precision electronic drive and high-accuracy metering pump deliver titrant volumes with exceptional repeatability (minimum single-drop volume of 10-20 µL), ensuring that API content determinations meet stringent regulatory and pharmacopoeial requirements (USP, Ph.Eur., ChP). For the patient, this ensures that every batch of medication has the correct potency and composition, free from over-dosage or under-dosage that could compromise therapeutic efficacy or cause toxicity.
2. Environmental Water Quality Analysis
  • Primary Use: Employed for determination of water hardness (total calcium and magnesium), chloride content, chemical oxygen demand (COD), and other key water quality indicators in drinking water, surface water, groundwater, and industrial wastewater.
  • How it helps: For the environmental analyst and public health laboratory technician, the dTrite-Pro’s ability to perform complexometric and precipitation titrations provides a rapid, precise, and standardized method for monitoring water quality. Its high-precision motorized control ensures that measurements for critical parameters like chloride (Mohr method) and water hardness are free from operator bias, producing traceable, defensible data. For the patient and community, this rigorous monitoring helps safeguard public drinking water supplies and ensures that industrial wastewater discharge complies with environmental regulations, protecting public health and ecosystems.
3. Food Safety and Nutritional Analysis
  • Primary Use: Utilized for quantitative determination of key quality and safety parameters in food products, including acid value and peroxide value of edible oils, salt content in processed foods, total acidity in beverages, and reducing sugars.
  • How it helps: For the food safety analyst and QA manager, the dTrite-Pro provides a portable, high-precision solution for ensuring compliance with food safety standards. Its automated visual endpoint recognition and controlled titration rate dramatically improve the accuracy and reproducibility of essential quality indices like acid value and peroxide value, aligning results with national food safety standards. For the patient (consumer), this ensures that food products are safe, fresh, and meet regulatory standards for quality, reducing the risk of consuming adulterated or rancid products.
4. Clinical Research and Biochemical Analysis
  • Primary Use: Supports clinical research and biochemical analysis in hospital and research laboratories, including quantification of calcium in biological samples, analysis of chloride in physiological solutions, and other specialized assays supporting clinical studies.
  • How it helps: For the research scientist and clinical laboratory technologist, the dTrite-Pro’s ability to handle trace volumes (as low as 10 µL for the 10mL model) with high precision is invaluable for developing and validating new analytical methods. Its full electronic control and data logging capabilities (up to 1000 records) ensure the creation of highly reproducible methods and a complete analytical audit trail. For the patient, this rigor generates reliable, traceable data used in clinical research to draw valid conclusions about patient health, disease mechanisms, or the efficacy of potential new therapies.

SECONDARY & SUPPORTIVE USES

1. Pharmaceutical Raw Material and Excipient Testing: Used for compendial analysis of incoming raw materials, including nitrogen content determination (Kjeldahl) and non-aqueous titrations for weak acids and bases as per pharmacopeial monographs.
2. Veterinary Drug Quality Control: Supports quality control of veterinary pharmaceuticals, including potency testing of antibiotics and quantitative analysis of active ingredients in animal health products.
3. Fertilizer and Agricultural Analysis: Used to determine nutrient content of fertilizers, such as total nitrogen and potassium levels, ensuring product quality for agricultural applications.
4. Petrochemical Industry Quality Control: Employed for analysis of acid number, base number, and mercaptan sulfur in petroleum products to determine product quality and corrosion potential.
5. Wine and Beverage Analysis: Controls quality of wine and beverages by measuring total acidity, pH, and free/total sulfur dioxide (SO₂), ensuring product consistency.
6. Cosmetic and Personal Care Product Testing: Performs quality control checks on cosmetic ingredients and finished products, such as measuring acid value of oils used in creams and lotions.
7. Electroplating and Metal Finishing QC: Used to analyze concentration of metal ions (e.g., nickel, copper, zinc) in electroplating baths, ensuring consistent plating quality.
8. Forensic and Toxicology Sample Preparation: Precisely prepares standards, calibrators, and QC samples for toxicological analysis by LC-MS/MS or GC-MS.
9. Academic and Educational Laboratory Training: Serves as a state-of-the-art teaching tool for students to learn titration principles while being introduced to modern automated analytical instrumentation.
10. Custom Method Development: Free, downloadable PC control software allows research laboratories to develop, optimize, and save custom titration methods for novel applications.
KEY PRODUCT FEATURES

1. BASIC IDENTIFICATION ATTRIBUTES

  • Device Type: A fully electronic, digitally controlled bottle-top titration system that replaces traditional manual and semi-automatic burettes for a wide range of analytical titration techniques.
  • Designation: dTrite-Pro Electronic Titrator, Electronic Digital Burette, dTrite-Pro Titration System.
  • Key Components:
o Electronic Drive Unit: Houses the motor, control electronics, and user interface with precision electronic drive.
o 4.3″ TFT Color Touchscreen: High-resolution (800×480) screen for intuitive operation, method selection, and data visualization.
o Detachable Remote Control Panel: Allows for remote titration, promoting user safety by operating away from chemical fumes and splashes.
o High-Precision Metering Pump: Electronic stepper motor driving a precision piston for exceptional volumetric accuracy.
o Interchangeable Burette Units: Available in 10mL, 25mL, and 50mL sizes for different titration volume requirements.
o Wetted Materials: Fluid path constructed from PTFE, FEP, and borosilicate glass for broad chemical compatibility.
o Removable Bottle Adapters: Set of 5 adapters for secure attachment to various reagent bottle threads.
o 0-90° Rotatable Built-in Valve: Enables rapid air exhaust and safe reagent return to storage bottle.
o Built-in Magnetic Stirrer: Optional stirring function for homogeneous sample mixing during titrations.
o Transparent and Brown (Amber) Windows: Brown window for light-sensitive titrants (iodine, potassium permanganate, silver nitrate) to prevent photodegradation.
o Drying Tube: Standard accessory for protecting moisture and CO₂-sensitive reagents from atmospheric contamination.
o PC Software (Free): Provided for computer control, method programming, data export, and LIMS connectivity.

2. TECHNICAL & PERFORMANCE PROPERTIES

  • Available Burette Volume Capacities: 10 mL, 25 mL, and 50 mL models.
  • Operating Volume Range: From 10 µL up to 50.00 mL (depending on model).
  • Minimum Single-Drop Volume: 10 µL (10 mL burette); 20 µL (25 mL and 50 mL burettes).
  • Delivery Speed: Adjustable over 10 levels, ranging from 0.5 mL/s up to 10 mL/s.
  • Performance Standards: ISO 8655 compliant; meets A-grade accuracy requirements for volumetric apparatus.
  • Display: 4.3-inch TFT color touchscreen with 800×480 resolution.
  • Data Storage Capacity: Memory for up to 1,000 complete titration records.
  • Power Supply: AC power via external adapter; built-in 3,500mAh rechargeable battery for extended field use.
  • Wireless Connectivity: Integrated Bluetooth and WiFi for remote control, PC linkage, and data management.
  • Operational Modes: Liquid dispensing (single drop, fixed volume, manual discharge); liquid aspiration (manual suction, fixed-volume aspiration).

3. PHYSICAL & OPERATIONAL PROPERTIES

  • Construction: Impact-resistant, chemically resistant polymer housing for benchtop use.
  • Liquid End Path: High chemical compatibility with PTFE, FEP, and borosilicate glass.
  • Window System: Supplied with both transparent and brown (amber) liquid windows for light-sensitive reagents.
  • User Interface: High-resolution 4.3″ color touchscreen plus detachable remote control panel.
  • Wireless Connectivity: Bluetooth and Wi-Fi built-in for connecting to PC software and LIMS.
  • PC Software: Free, downloadable software to control the unit, design methods, and manage/export data records.
  • Data Management: Stores up to 1,000 individual titration records including date, time, volume, and method parameters.
  • LIMS Compatibility: PC software allows seamless integration of titration data into Laboratory Information Management Systems.
  • Drying Tube: Standard accessory to protect reagents from moisture and CO₂.
  • Portability: Lightweight construction and 3500mAh battery allow untethered operation for field and mobile workflows.

4. SAFETY & COMPLIANCE ATTRIBUTES

  • Regulatory Status: Class I general laboratory equipment.
  • Safety Features: Remote operation via detachable panel and wireless control; 0-90° rotatable valve for safe reagent return; brown window prevents photodegradation of light-sensitive titrants.
  • Quality Compliance: Designed, manufactured, and tested to meet ISO 8655 standards and GLP/GMP guidelines for data management and traceability.
  • Chemical Compatibility: Liquid contact parts made of PTFE, FEP, and borosilicate glass; not suitable for hydrofluoric acid (HF).

5. STORAGE & HANDLING ATTRIBUTES

  • Storage: Store main unit in a clean, dry, chemical-free area when not in use.
  • Cleaning: Clean external housing and touchscreen with a soft, damp cloth and mild, non-abrasive detergent; disconnect power before cleaning.
  • Inspection: Inspect PTFE piston, glass cylinder, and seals for wear, cracking, or damage before first use and periodically thereafter.
  • Operation and Setup: Ensure PP and PTFE seals are of good quality; when changing reagents, flush system thoroughly with compatible solvent to avoid cross-contamination.
  • Temperature Sensitivity: Equilibrate all reagents to room temperature (10-30°C) before use for volumetric accuracy.
  • Battery Management: For battery-operated use, ensure unit is fully charged; store with partial battery charge for extended periods.
  • Calibration: Regular calibration verification of piston recommended to maintain ISO 8655 compliance and long-term accuracy.

6. LABORATORY & CLINICAL APPLICATIONS

  • Primary Application: High-precision electronic titration for quantitative chemical analysis in pharmaceutical quality control, environmental monitoring, food safety testing, and chemical quality control laboratories.
  • Clinical Role: Supports diagnostic and clinical processes indirectly by providing accurate, traceable analytical data for pharmaceutical QC, environmental safety monitoring, and preparation of high-accuracy standards for calibrators used in clinical chemistry analyzers and immunoassays.
SAFETY HANDLING PRECAUTIONS

1. SAFETY PRECAUTIONS

  • Electrical Safety: Operate only with supplied AC power adapter; do not immerse control unit or touchscreen in liquid.
  • Chemical Hazards: Titration may involve corrosive, toxic, or flammable reagents; handle in chemical fume hood with appropriate PPE (gloves, eye protection, lab coat); use remote control feature to maintain safe distance.
  • Spill Containment: Work with instrument in spill tray large enough to contain entire reagent bottle contents.
  • Chemical Compatibility: Consult manufacturer's chemical compatibility guide before using new reagents; hydrofluoric acid (HF) is incompatible and will damage glass fluid path and PTFE seals.
  • Pressure: Never exceed maximum operating pressure of internal pump.
  • Autoclaving: Main electronic unit and PTFE piston are not autoclavable.

2. FIRST AID MEASURES

  • Chemical Splash: Remove contaminated clothing immediately; rinse affected skin with copious water for at least 15 minutes; for eye contact, rinse with water or saline for 15 minutes and seek immediate medical attention; refer to chemical's Safety Data Sheet (SDS).
  • Inhalation: Move person to fresh air immediately; seek medical attention if coughing, shortness of breath, or dizziness persist.
  • Ingestion: Do NOT induce vomiting unless directed by medical professional; rinse mouth with water and immediately seek medical attention, taking chemical's SDS.

3. FIRE FIGHTING MEASURES

  • Flammability: Plastic housing is combustible but not primary fuel source; primary fire risk comes from flammable reagents being used.
  • Extinguishing Media: Use multi-purpose ABC dry chemical fire extinguisher, alcohol-resistant foam, or CO₂ for fires involving electrical components or flammable reagents.
  • Fire Response: Disconnect power supply immediately if safe to do so; do not use water on electrical fire.