Electronic Titrator (dTrite-S)

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The Electronic Titrator (dTrite-S) is a high-precision, digitally controlled bottle-top titration system designed to replace traditional manual glass burettes for accurate quantitative analysis in pharmaceutical QC, environmental monitoring, food safety, and clinical research laboratories. Leveraging a precision electronic drive (R=0.2%, CV=0.07%) and 16 adjustable speed levels, it automates the titration workflow, eliminating manual errors related to drop control and subjective endpoint detection. The system features a large LCD display, a remote control panel for safe distance operation, and USB connectivity for data storage and computer control. Its wide working range (0.010-99.999mL) and minimum dispensing volume of 10 μL make it versatile for various analytical applications.
Description

Electronic Titrator (dTrite-S)

PRIMARY CLINICAL & DIAGNOSTIC USES

1. Quality Control of Active Pharmaceutical Ingredients
  • Primary Use: Provides a fully electronic, digitally controlled bottle-top titration system designed for precise quantitative analysis of active pharmaceutical ingredients (APIs) and excipients, ensuring pharmaceutical products meet regulatory potency and purity standards.
  • How it helps: For the pharmaceutical quality control chemist, the dTrite-S’s precision electronic drive (R=0.2%, CV=0.07%) eliminates manual titration errors, ensuring accurate API content determination. Its 16 adjustable speed levels allow optimal control for different reaction kinetics. For the patient, this ensures every medication batch has the correct dosage and purity, directly supporting treatment efficacy and safety.
2. Water Quality Testing for Dialysis and Critical Care
  • Primary Use: Used for determining water hardness, chloride content, and other critical parameters in purified water systems, ensuring water used for dialysis and sterile processing meets stringent safety standards.
  • How it helps: For the water quality specialist and dialysis center manager, the dTrite-S performs complexometric and precipitation titrations with high repeatability, providing traceable, defensible data for regulatory compliance. Its wide working range (0.010mL-99.999mL) accommodates diverse sample types. For the patient, this rigorous monitoring safeguards against waterborne contaminants in dialysis treatment, directly protecting patient health.
3. Food Safety and Nutritional Analysis
  • Primary Use: Quantitatively determines key food quality parameters, including acid value and peroxide value of edible oils, salt content in processed foods, and total acidity in beverages.
  • How it helps: For the food safety analyst, the dTrite-S’s automated endpoint recognition and controlled titration rate dramatically improve the accuracy and reproducibility of these essential quality indices, aligning results with national food safety standards. For the patient, this helps ensure food products are safe, fresh, and meet regulatory quality standards, reducing the risk of consuming adulterated or rancid products.
4. Clinical Research and Biochemical Analysis
  • Primary Use: Supports clinical research by precisely quantifying calcium in biological samples, analyzing chloride in physiological solutions, and performing other specialized assays that support clinical studies.
  • How it helps: For the research scientist, the dTrite-S’s ability to handle trace volumes (minimum 10 μL) with high precision is invaluable for developing and validating new analytical methods. Its full electronic control and data logging capabilities support GLP/GMP compliance. For the patient, this rigor generates reliable, traceable data used in clinical research to draw valid conclusions about patient health, disease mechanisms, or the efficacy of potential new therapies.

SECONDARY & SUPPORTIVE USES

1. Pharmaceutical Raw Material and Excipient Testing: Used for compendial analysis of incoming raw materials, including non-aqueous titrations for weak acids and bases, as required by pharmacopeial monographs.
2. Veterinary Drug Quality Control: Supports quality control of veterinary pharmaceuticals, including potency testing of antibiotics and quantitative analysis of active ingredients in animal health products.
3. Fertilizer and Agricultural Analysis: Used to determine nutrient content of fertilizers, such as total nitrogen (Kjeldahl method) and potassium levels, ensuring product quality for agricultural applications.
4. Petrochemical Industry Quality Control: Employed for analysis of acid number, base number, and mercaptan sulfur in petroleum products to determine product quality and corrosion potential.
5. Wine and Beverage Analysis: Controls the quality of wine and beverages by measuring total acidity, pH, and free/total sulfur dioxide (SO₂), ensuring product consistency.
6. Cosmetic and Personal Care Product Testing: Performs quality control checks on cosmetic ingredients and finished products, such as measuring the acid value of oils used in creams and lotions.
7. Electroplating and Metal Finishing QC: Used to analyze the concentration of metal ions (e.g., nickel, copper, zinc) in electroplating baths, ensuring consistent plating quality.
8. Forensic and Toxicology Sample Preparation: Precisely prepares standards, calibrators, and QC samples for toxicological analysis by LC-MS/MS or GC-MS, where precise concentration accuracy is critical for quantification.
9. Academic and Educational Laboratory Training: Serves as a state-of-the-art teaching tool for students to learn titration principles while being introduced to modern automated analytical instrumentation.
10. Custom Method Development: The USB connectivity allows for remote control and data storage, enabling research laboratories to develop, optimize, and save custom titration methods for novel applications.
KEY PRODUCT FEATURES

1. BASIC IDENTIFICATION ATTRIBUTES

  • Device Type: A fully electronic, digitally controlled bottle-top titration system that replaces traditional manual and semi-automatic burettes for a wide range of analytical titration techniques.
  • Designation: dTrite-S Electronic Titrator, Electronic Digital Burette, DLAB dTrite-S.
  • Key Components:
o Electronic Drive Unit: Houses the motor, control electronics, and user interface with precision electronic drive.
o Large LCD Display: Humanized large-size LCD parameter setting interactive panel.
o Remote Control Panel: Detachable panel allows for remote titration, promoting user safety by operating away from chemical fumes and splashes.
o High-Precision Metering Pump: Electronic stepper motor driving a precision piston for exceptional volumetric accuracy.
o Interchangeable Burette Units: Single maximum pipetting volume of 10 mL; minimum dispensing volume of 10 μL.
o Wetted Materials: Fluid path constructed from chemically resistant materials for broad chemical compatibility.
o Removable Bottle Adapters: For secure attachment to various reagent bottle threads.
o External Magnetic Stirrer: Supports automated stirring for homogeneous sample mixing during titrations.
o USB Connectivity: Supports connection to a computer for remote control and data storage.

2. TECHNICAL & PERFORMANCE PROPERTIES

  • Working Range: 0.010 mL - 99.999 mL.
  • Maximum Piston Lift: 10 mL; Minimum Dispensing Volume: 10 μL.
  • Accuracy (Systematic Error): R=0.2% (at 10mL), R=1% (at 1mL).
  • Precision (CV): CV=0.07% (at 10mL), CV=0.1% (at 5mL), CV=0.5% (at 1mL).
  • Speed Settings: 16 adjustable levels.
  • Operating Temperature Range: 10-30°C.
  • Quality Standards: Compliant with DIN EN ISO 8655.
  • Control Mode: Supports remote control, can be connected to host computer software.
  • Application Areas: Chemical analysis, food industry, environmental analysis.

3. PHYSICAL & OPERATIONAL PROPERTIES

  • Construction: High-quality, durable components for long-term laboratory use.
  • User Interface: Large LCD display for clear visualization of parameters; remote control panel for safe distance operation.
  • Operation: Fully digital, motor-driven control eliminating manual fatigue.
  • Data Management: Supports data storage and transfer; can be connected to a computer via USB for remote control and data saving.
  • Cleaning and Maintenance: Easy to clean; fluid path components are resistant to a wide range of laboratory chemicals.
  • Portability: Benchtop design; can be used with a variety of reagent bottles.

4. SAFETY & COMPLIANCE ATTRIBUTES

  • Regulatory Status: General laboratory equipment for analytical testing; compliant with ISO 8655.
  • Safety Features: Remote control operation allows operator to work safely away from chemical splashes and fumes.
  • Electrical Safety: Operates on low voltage via external AC adapter.
  • Chemical Safety: Constructed with chemically resistant materials; designed to be used with a wide range of acids, bases, and solvents.

5.  STORAGE & HANDLING ATTRIBUTES

  • Storage: Store in a clean, dry, chemical-free area when not in use.
  • Cleaning: Clean external housing with a soft, damp cloth; use mild, non-abrasive detergent.
  • Inspection: Regularly inspect the piston and seals for signs of wear or damage.
  • Operation and Setup: Ensure proper assembly of the burette unit and secure attachment to the reagent bottle. Use an external magnetic stirrer for automated mixing.
  • Temperature Sensitivity: Equilibrate all reagents to room temperature (10-30°C) before use for optimal volumetric accuracy.
  • Calibration: Periodic calibration verification is recommended to maintain ISO 8655 compliance and long-term accuracy. 
SAFETY HANDLING PRECAUTIONS

1. FIRST AID MEASURES

  • Chemical Splash: In case of a chemical splash, immediately remove contaminated clothing and rinse the affected skin with copious water for at least 15 minutes. For eye contact, rinse with water or saline for 15 minutes and seek immediate medical attention. Refer to the chemical's Safety Data Sheet (SDS).
  • Inhalation: If chemical vapors are inhaled, move the person to fresh air immediately. Seek medical attention if coughing, shortness of breath, or dizziness persist.
  • Ingestion: Do NOT induce vomiting unless directed to do so by a medical professional. Rinse mouth with water and immediately seek medical attention, taking the chemical's SDS with you.

2. FIRE FIGHTING MEASURES

  • Flammability: The plastic housing is combustible, but the primary fire risk comes from the flammable reagents being used.
  • Extinguishing Media: Use a multi-purpose ABC dry chemical fire extinguisher, alcohol-resistant foam, or CO₂ for fires involving electrical components or flammable reagents.
  • Fire Response: Disconnect the power supply immediately if it is safe to do so. Do not use water on an electrical fire.