High Shear Homogenizer (D-500)

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The High Shear Homogenizer is a powerful benchtop rotor-stator homogenizer featuring a 500W AC carbon brush motor, variable speed control (10,000-30,000 rpm with 6 speed settings), interchangeable autoclavable 316L stainless steel dispersing shafts, and a wide working volume range of 10-40,000 mL, designed for rapid homogenization, dispersion, and emulsification of biological tissues, pharmaceutical formulations, and chemical samples in clinical diagnostic, pharmaceutical, and research laboratories .

Key features include a 500W high-power motor handling samples up to 10,000 mPa·s viscosity , 6-stage adjustable speed dial for precise control of homogenization intensity , interchangeable dispersing shafts ( High Shear Homogenize/1 for solid-liquid mixing and tissue homogenization; High Shear Homogenize/2 for emulsification and cream preparation) , fully autoclavable 316L stainless steel construction with PTFE seals for chemical resistance and contamination prevention, automatic overload protection and smooth motor start for safety and extended motor life, emergency stop safety switch for immediate shutdown, and compact (75 × 75 × 280 mm) and lightweight (1.7 kg) design for benchtop or stand-mounted operation . An optional H-600 stand enables hands-free, stationary operation .

For the histotechnologist and pathologist, the High Shear Homogenize processes tough tissue samples such as muscle, liver, breast, and other organs in seconds—enabling rapid preparation of homogenized specimens for histological examination, immunohistochemistry, and diagnostic pathology . For the molecular biologist, it supports cell disruption and nucleic acid extraction for PCR-based infectious disease testing, genetic screening, and oncology biomarker detection. For the pharmaceutical QC chemist, it processes high-viscosity formulations, creams, and ointments for stability testing and quality release.

For the patient undergoing biopsy for suspected cancer, inflammatory disease, or infectious condition, the High Shear Homogenize rapid tissue homogenization reduces turnaround time for diagnostic results, enabling earlier diagnosis and treatment initiation . For patients requiring pharmaceutical products, consistent formulation testing ensures that medications, topical creams, and biological products meet quality standards for safety and efficacy. For patients requiring molecular diagnostic testing, efficient cell lysis and nucleic acid extraction ensure accurate PCR and sequencing results that guide appropriate treatment decisions across clinical pathology, molecular diagnostics, infectious disease testing, and pharmaceutical quality control applications.

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Categories: LABORATORY EQUIPMENT AND SUPPLIES, Lab Consumables Tags: Cell Lysis, Clinical Laboratory Equipment, D-500 Homogenizer, Dispersion, DLAB High Shear Homogenize, Emulsification, High Shear Homogenizer, High Speed Homogenizer, Histopathology Equipment, Laboratory Homogenizer, Pharmaceutical QC Equipment, Rotor-Stator Homogenizer, Sample Preparation, Tissue Homogenizer

Description

High Shear Homogenizer

PRIMARY CLINICAL & DIAGNOSTIC USES

1. High-Performance Tissue Homogenization for Histopathology

Primary Use: Provides a benchtop high shear homogenizer with a powerful 500W motor, variable speed control (10,000-30,000 rpm with 6 speed settings), interchangeable 316L stainless steel dispersing shafts, and a wide working volume range of 10-40,000 mL for rapid homogenization of biological tissues, organs, and cells for pathological analysis .
How it helps: For the histotechnologist and pathologist, the High Shear Homogenize processes tough tissue samples such as muscle, liver, breast, and other organs in seconds—enabling rapid preparation of homogenized specimens for histological examination, immunohistochemistry, and diagnostic pathology. The high shear rotor-stator mechanism (up to 36 m/sec linear velocity) ensures complete tissue disruption even for fibrous samples . For the patient, faster tissue processing reduces turnaround time for biopsy results, enabling earlier diagnosis of cancers, inflammatory conditions, and infectious diseases.

2. Sample Preparation for Molecular Diagnostics and PCR

Primary Use: Used for cell disruption, lysis, and homogenization of biological samples before nucleic acid extraction (DNA/RNA) and protein purification for molecular diagnostic workflows .
How it helps: For the molecular biologist and clinical laboratory scientist, the High Shear Homogenize efficiently lyses cells and releases intracellular contents from animal and plant tissues, enabling high-yield extraction of nucleic acids and proteins from biopsy specimens, surgical resections, and cultured cells. The fully autoclavable 316L stainless steel dispersing shafts prevent sample cross-contamination . For the patient undergoing genetic testing for hereditary disorders, infectious diseases, or oncology biomarkers, efficient cell lysis ensures accurate PCR and sequencing results that guide treatment decisions.

3. High-Viscosity Sample Processing for Biopharmaceutical Testing

Primary Use: Capable of processing samples with viscosity up to 10,000 mPa·s, enabling homogenization and emulsification of viscous biological fluids, creams, ointments, and pharmaceutical formulations for quality control and formulation testing .
How it helps: For the pharmaceutical quality control chemist and formulation scientist, the High Shear Homogenize high torque 500W motor and wide speed range provide efficient processing of high-viscosity samples—ensuring consistent emulsification of creams, lotions, and ointments for stability testing and quality release. For the patient, consistent pharmaceutical formulation testing ensures that medications, topical creams, and biological products meet quality standards for safety and efficacy.

4. Pathological Analysis of Large-Volume Biopsy and Surgical Specimens

Primary Use: Facilitates homogenization of large-volume biopsy specimens and surgical resection tissues (up to 40,000 mL) for pathological analysis, enzyme activity assays, and biomarker quantification .
How it helps: For the pathologist and clinical researcher, the D-500’s wide working volume range (10-40,000 mL) allows homogenization of both small needle biopsies and large surgical resection specimens—enabling comprehensive analysis of limited diagnostic material as well as bulk tissue processing. For the patient, the ability to process a wide range of specimen volumes reduces the need for repeat procedures and enables complete pathological evaluation of removed tissues.

5. Emulsification and Dispersion for Quality Control Testing

Primary Use: Used for emulsification of lipid-containing samples, dispersion of active pharmaceutical ingredients, and homogenization of complex biological fluids for clinical chemistry and pharmaceutical quality control testing .
How it helps: For the clinical chemist and pharmaceutical QC scientist, the High Shear Homogenize high shear rotor-stator mechanism (up to 79 dB(A) noise level) creates stable emulsions and dispersions of lipid-rich samples, lipoproteins, API suspensions, and other complex formulations—enabling accurate measurement of active ingredients, particle size distribution, and formulation stability . For the patient, consistent sample emulsification ensures reliable quality control results that guide pharmaceutical manufacturing and clinical laboratory testing.

SECONDARY & SUPPORTIVE USES

1. Biopharmaceutical Research and Development: Used for cell lysis, protein extraction, and formulation development in biopharmaceutical discovery and manufacturing workflows.

2. Gene Research and Genetic Analysis: Supports tissue homogenization for DNA/RNA extraction in clinical genetics laboratories and molecular diagnostics .

3. Active Pharmaceutical Ingredient (API) Extraction: Facilitates extraction of active pharmaceutical ingredients from tablets, pills, and other solid dosage forms for content uniformity testing .

4. Oil-Water Emulsification for Cosmetic and Pharmaceutical Testing: Supports preparation of emulsions and creams for quality control testing of cosmetic and pharmaceutical products .

5. Oral Solid Dosage Form Disintegration Testing: Used for homogenization of tablets and capsules for dissolution testing and API release analysis.

6. Parenteral Drug Product Testing: Supports homogenization of injectable formulations for particle size analysis and stability studies.

7. Dairy and Food Homogenization: Used for homogenization of dairy products and food samples for nutritional labeling and safety testing .

8. Nanomaterial Dispersion for Diagnostic Assays: Helps disperse nanoparticles and microparticles for diagnostic assay development and quality control .

9. Polymerization and Chemical Reaction Preparation: Supports mixing and homogenization in chemical reaction preparation for polymer synthesis.

10. Paint, Ink, and Coating Homogenization: Used for dispersion of pigments and additives in paint, ink, and coating manufacturing quality control .

11. Fine Chemicals and Pesticide Testing: Used for homogenization of chemical samples in fine chemical and pesticide quality control laboratories.

12. Active Ingredient Extraction from Natural Products: Supports extraction of active compounds from botanical materials for nutraceutical and pharmaceutical development.

13. Environmental Sample Processing: Helps homogenize soil, water, and environmental samples for pollutant analysis and environmental monitoring .

14. Prospecting and Mining Sample Preparation: Supports homogenization of geological and mineral samples for element analysis and mineral exploration .

15. Veterinary Diagnostic Laboratory: Processes tissue and fluid samples for animal health testing and infectious disease diagnosis.

16. Research and Academic Laboratories: Provides high shear homogenization for diverse research applications in cell biology, biochemistry, and biotechnology.

17. Nanoparticle Synthesis and Dispersion: Supports dispersion of nanoparticles and microparticles for drug delivery research and formulation development.

18. Textile Chemical Quality Control: Used for homogenization of textile auxiliaries and finishing agents for quality testing .

19. Cosmetics Formulation Development: Supports formulation of creams, lotions, gels, and other cosmetic products.

KEY PRODUCT FEATURES

1. BASIC IDENTIFICATION ATTRIBUTES

Device Type: A benchtop high shear homogenizer (rotor-stator homogenizer) with variable speed control (10,000-30,000 rpm, 6 speed levels), interchangeable autoclavable dispersing shafts, and wide working volume range, designed for rapid homogenization, dispersion, and emulsification of biological tissues, pharmaceutical formulations, and chemical samples in clinical diagnostic, pharmaceutical, and research laboratories .
Designation: High Shear Homogenizer, High Shear Homogenizer, D-500 Homogenizer, DLAB High Shear Homogenize, Laboratory Homogenizer, High Speed Homogenizer, Bench-top Homogenizer .
Key Components:

o Drive Motor: AC carbon brush motor, 500W input power .
o Speed Control: 6-stage adjustable speed dial (10,000-30,000 rpm) .
o Dispersing Shafts: Interchangeable 316L stainless steel shafts with PTFE seals (DS-500/1 for solid-liquid mixing; DS-500/2 for emulsification) .
o Stand: H-600 stand for hands-free, stationary operation .
o Housing: Compact benchtop design, 75x75x280 mm dimensions .
o Safety Features: Automatic overload protection, smooth motor start, emergency stop safety switch .

2. TECHNICAL & PERFORMANCE PROPERTIES

Speed Range: 10,000-30,000 rpm (6 speed settings) .
Maximum Rotor Linear Velocity: 22.7-36 m/sec .
Working Volume: 10-40,000 mL (10-5000 mL with DS-500/1 or DS-500/2 shafts) .
Maximum Viscosity: 10,000 mPa·s .
Motor Type: AC carbon brush motor .
Motor Power: 500W .
Speed Display: Rotary dial with 6 positions .
Noise Level: ≤79 dB(A) .
Dispersing Shaft Material: SS 316L stainless steel (corrosion-resistant, autoclavable) .
Seal Material: PTFE (chemically inert, autoclavable) .
pH Range: 2-13 .
Fineness: Suspensions & Emulsion 10-15 µm & 1-10 µm .
Power Requirements: 110-120V/60Hz or 220-240V/50-60Hz (universal voltage) .
Dimensions (L × W × H): 75 × 75 × 280 mm (drive only) .
Weight: 1.7 kg .
Operating Temperature: 0-40°C .
Permissible Ambient Humidity: up to 85% RH .
Protection Class: IP20 .
Safety Features: Automatic overload protection; smooth motor start; emergency stop safety switch; thermal fuse for overload protection .

3. PHYSICAL & OPERATIONAL PROPERTIES

Construction: Compact benchtop design with lightweight (1.7 kg) drive unit; ergonomic grip for handheld operation; optional H-600 stand for hands-free, stationary use .
Dispersing Shafts: Interchangeable shafts with tool-free attachment; fully autoclavable 316L stainless steel construction; PTFE seal rings for chemical resistance; available in two configurations: DS-500/1 for solid-liquid mixing, DS-500/2 for emulsification .
Principle: Rotor-stator mechanism where samples are drawn into the core of the homogenizer by a rotor turning at high speed (10,000-30,000 rpm), then forced through narrow slits in the stator where high shear forces cause rapid tissue disruption, emulsification, and cell lysis .
Control: 6-stage rotary speed dial with positions for precise adjustment of homogenization intensity .
Operation Modes: Handheld mode for manual operation; H-600 stand mode for hands-free, stationary operation .
Safety Features: Automatic overload protection extends motor lifespan ; smooth motor start prevents splashing and sample loss ; emergency stop safety switch for immediate shutdown .
Portability: Compact (75 × 75 × 280 mm) and lightweight (1.7 kg) for easy transport between workstations and benchtop storage.
Maintenance: Dispersing shafts are easily disassembled without specialized tools for cleaning and sterilization; AC carbon brush motor requires periodic brush replacement .

4. SAFETY & COMPLIANCE ATTRIBUTES

Regulatory Status: General laboratory equipment for research and in vitro diagnostic use; meets applicable laboratory safety standards .
Safety Features: IP20 protection rating provides protection against solid objects >12mm; automatic overload protection mechanism maximizes motor working life; smooth motor start prevents splashing and sample loss; emergency stop safety switch for immediate shutdown .
Electrical Safety: Universal voltage (100-240V, 50/60Hz) for international use; 500W power consumption; earthed power connection recommended; thermal fuse for overload protection .
Noise Control: ≤79 dB(A) operation level; insulated motor housing keeps motor noise to safe, approved level .
Material Safety: SS 316L stainless steel (corrosion-resistant, biocompatible, autoclavable); PTFE seals (chemically inert, biocompatible, autoclavable) .
Sterilization Compatibility: Dispersing shafts are fully autoclavable at 121°C for aseptic applications .
Certifications: CE certified; meets applicable safety standards .

5. STORAGE & HANDLING ATTRIBUTES

Storage: Store drive unit on clean, dry benchtop or in designated storage area; dispersing shafts should be cleaned and dried before storage; H-600 stand provides convenient storage for drive unit and shaft during idle periods .
Cleaning: Dispersing shafts: disassemble without tools, rinse with distilled water, clean with mild detergent, rinse thoroughly; autoclavable at 121°C for sterilization . Drive unit: wipe exterior with soft, damp cloth using neutral detergent; 70% ethanol solution may be used for surface disinfection; do not immerse drive unit in liquid; disconnect power before cleaning.
Inspection: Inspect dispersing shafts for damage (bent shafts, worn PTFE seals, corrosion) before each use; verify shaft is securely attached to drive unit; inspect power cord for damage before each use; check stand stability before mounting drive unit .
Operation: Secure sample container in stand or clamp; select appropriate dispersing shaft for sample volume and viscosity; attach shaft to drive unit; immerse shaft into sample (avoid touching container bottom); select speed setting (1-6); start motor; process sample until homogenized (typically 10-30 seconds for tissue) .
Shaft Selection: Use High Shear Homogenize/1 shaft for solid-liquid mixing, tissue homogenization, and general dispersion; use High Shear Homogenize/2 shaft for emulsification, cream preparation, and oil-water mixing .
Speed Selection: Use lower speeds (position 1-2) for soft tissues and cell suspensions; use medium speeds (position 3-4) for muscle, liver, and organ tissues; use higher speeds (position 5-6) for tough tissues, fibrous materials, high-viscosity samples, and emulsion preparation .
Aseptic Technique: For sterile applications, use autoclaved dispersing shafts and perform homogenization in biosafety cabinet; avoid aerosol generation.
Stand Use: For hands-free operation, mount drive unit on H-600 stand; secure stand on stable benchtop; clamp sample container in position; lower drive unit so shaft is properly immersed; operate with both hands free .
Spill Management: If sample spills onto drive unit, disconnect power immediately, clean thoroughly with appropriate disinfectant, allow to dry before reuse.

6. LABORATORY & CLINICAL APPLICATIONS

Primary Application: High shear homogenization, dispersion, and emulsification of biological tissues (muscle, liver, breast, organs), cells, clinical specimens, pharmaceutical formulations, and chemical samples for histopathology, molecular diagnostics, cytology, clinical chemistry, pharmaceutical quality control, and research laboratories .
Clinical Role: Essential sample preparation equipment in histopathology laboratories, molecular diagnostics labs, clinical chemistry laboratories, microbiology labs, cytology labs, pharmaceutical QC laboratories, biotechnology research facilities, and academic research institutions .

SAFETY HANDLING PRECAUTIONS

1. SAFETY PRECAUTIONS

Electrical Safety: Disconnect power before cleaning or changing dispersing shafts; do not immerse drive unit in liquid; keep power cord away from heat sources and sharp edges; use only properly grounded electrical outlets; use emergency stop safety switch for immediate shutdown if needed .
Aerosol Generation: High-speed homogenization may generate aerosols; use appropriate containment (biosafety cabinet, fume hood) when processing infectious materials, hazardous chemicals, or volatile solvents.
Personal Protective Equipment: Wear appropriate PPE—laboratory coat, safety glasses/face shield, gloves—when operating homogenizer; use cut-resistant gloves when handling and cleaning dispersing shafts.
Shaft Selection: Select appropriate dispersing shaft for sample volume and viscosity; using smaller shaft in larger volume may reduce efficiency; using larger shaft in smaller volume may cause splashing and sample loss.
Sample Container: Use appropriate container (beaker, vessel) with sufficient diameter and depth for dispersing shaft; avoid using flimsy or uncapped tubes; clamp container securely when using stand-mounted operation.
Operation Precautions: Never operate homogenizer with shaft out of liquid; this may damage PTFE seals and cause overheating. Ensure shaft is fully immersed before starting motor. Do not process samples containing hard particles (glass, metal, hard plastics) that may damage rotor-stator assembly .
Noise Exposure: At ≤79 dB(A), noise level is below occupational exposure limits; however, extended operation may cause fatigue; use hearing protection if operating for prolonged periods.
Sharp Edges: Dispersing shafts contain sharp rotor-stator edges; handle with care to avoid cuts.
Cleaning: Clean dispersing shafts immediately after use to prevent dried sample residue; do not use abrasive cleaners on shafts.
Training: Only trained laboratory personnel should operate the High Shear Homogenizer for clinical diagnostic applications.

2. FIRST AID MEASURES

Sample Splash: If biological sample splashes into eyes, flush with water for 15 minutes, seek medical attention; if on skin, wash with soap and water.
Electrical Malfunction: If unit shows signs of electrical malfunction (smoke, burning smell, sparking), press emergency stop safety switch, disconnect power immediately; do not attempt to operate; contact service personnel .
Mechanical Failure: If unit fails to operate, makes abnormal noise, or vibrates excessively, disconnect power, inspect shaft for damage or debris, contact service if issue persists.
Sharp Edge Injury: If cut by dispersing shaft, clean wound thoroughly with soap and water, apply appropriate dressing, seek medical attention if bleeding persists or wound is deep.
Chemical Spill: If corrosive chemicals spill on unit, disconnect power immediately, wipe with appropriate neutralizer, dry thoroughly before reconnecting power.

3. FIRE FIGHTING MEASURES

Flammability: Plastic housing and electrical components may burn; AC carbon brush motor may produce sparks during normal operation.
Extinguishing Media: Use carbon dioxide (CO₂) or dry chemical extinguisher for electrical fires.
Fire Response: Press emergency stop safety switch, unplug unit immediately; do not use water on electrical fire; if sparks or smoke are observed during normal operation, discontinue use and service unit .

High Shear Homogenizer (D-500)

High Shear Homogenizer

PRIMARY CLINICAL & DIAGNOSTIC USES

1. High-Performance Tissue Homogenization for Histopathology

2. Sample Preparation for Molecular Diagnostics and PCR

Primary Use: Used for cell disruption, lysis, and homogenization of biological samples before nucleic acid extraction (DNA/RNA) and protein purification for molecular diagnostic workflows .

3. High-Viscosity Sample Processing for Biopharmaceutical Testing

Primary Use: Capable of processing samples with viscosity up to 10,000 mPa·s, enabling homogenization and emulsification of viscous biological fluids, creams, ointments, and pharmaceutical formulations for quality control and formulation testing .

4. Pathological Analysis of Large-Volume Biopsy and Surgical Specimens

Primary Use: Facilitates homogenization of large-volume biopsy specimens and surgical resection tissues (up to 40,000 mL) for pathological analysis, enzyme activity assays, and biomarker quantification .

5. Emulsification and Dispersion for Quality Control Testing

Primary Use: Used for emulsification of lipid-containing samples, dispersion of active pharmaceutical ingredients, and homogenization of complex biological fluids for clinical chemistry and pharmaceutical quality control testing .

SECONDARY & SUPPORTIVE USES

1. Biopharmaceutical Research and Development: Used for cell lysis, protein extraction, and formulation development in biopharmaceutical discovery and manufacturing workflows.

2. Gene Research and Genetic Analysis: Supports tissue homogenization for DNA/RNA extraction in clinical genetics laboratories and molecular diagnostics .

3. Active Pharmaceutical Ingredient (API) Extraction: Facilitates extraction of active pharmaceutical ingredients from tablets, pills, and other solid dosage forms for content uniformity testing .

4. Oil-Water Emulsification for Cosmetic and Pharmaceutical Testing: Supports preparation of emulsions and creams for quality control testing of cosmetic and pharmaceutical products .

5. Oral Solid Dosage Form Disintegration Testing: Used for homogenization of tablets and capsules for dissolution testing and API release analysis.

6. Parenteral Drug Product Testing: Supports homogenization of injectable formulations for particle size analysis and stability studies.

7. Dairy and Food Homogenization: Used for homogenization of dairy products and food samples for nutritional labeling and safety testing .

8. Nanomaterial Dispersion for Diagnostic Assays: Helps disperse nanoparticles and microparticles for diagnostic assay development and quality control .

9. Polymerization and Chemical Reaction Preparation: Supports mixing and homogenization in chemical reaction preparation for polymer synthesis.

10. Paint, Ink, and Coating Homogenization: Used for dispersion of pigments and additives in paint, ink, and coating manufacturing quality control .

11. Fine Chemicals and Pesticide Testing: Used for homogenization of chemical samples in fine chemical and pesticide quality control laboratories.

12. Active Ingredient Extraction from Natural Products: Supports extraction of active compounds from botanical materials for nutraceutical and pharmaceutical development.

13. Environmental Sample Processing: Helps homogenize soil, water, and environmental samples for pollutant analysis and environmental monitoring .

14. Prospecting and Mining Sample Preparation: Supports homogenization of geological and mineral samples for element analysis and mineral exploration .

15. Veterinary Diagnostic Laboratory: Processes tissue and fluid samples for animal health testing and infectious disease diagnosis.

16. Research and Academic Laboratories: Provides high shear homogenization for diverse research applications in cell biology, biochemistry, and biotechnology.

17. Nanoparticle Synthesis and Dispersion: Supports dispersion of nanoparticles and microparticles for drug delivery research and formulation development.

18. Textile Chemical Quality Control: Used for homogenization of textile auxiliaries and finishing agents for quality testing .

19. Cosmetics Formulation Development: Supports formulation of creams, lotions, gels, and other cosmetic products.

1. BASIC IDENTIFICATION ATTRIBUTES

Designation: High Shear Homogenizer, High Shear Homogenizer, D-500 Homogenizer, DLAB High Shear Homogenize, Laboratory Homogenizer, High Speed Homogenizer, Bench-top Homogenizer .

Key Components:

2. TECHNICAL & PERFORMANCE PROPERTIES

Speed Range: 10,000-30,000 rpm (6 speed settings) .

Maximum Rotor Linear Velocity: 22.7-36 m/sec .

Working Volume: 10-40,000 mL (10-5000 mL with DS-500/1 or DS-500/2 shafts) .

Maximum Viscosity: 10,000 mPa·s .

Motor Type: AC carbon brush motor .

Motor Power: 500W .

Speed Display: Rotary dial with 6 positions .

Noise Level: ≤79 dB(A) .

Dispersing Shaft Material: SS 316L stainless steel (corrosion-resistant, autoclavable) .

Seal Material: PTFE (chemically inert, autoclavable) .

pH Range: 2-13 .

Fineness: Suspensions & Emulsion 10-15 µm & 1-10 µm .

Power Requirements: 110-120V/60Hz or 220-240V/50-60Hz (universal voltage) .

Dimensions (L × W × H): 75 × 75 × 280 mm (drive only) .

Weight: 1.7 kg .

Operating Temperature: 0-40°C .

Permissible Ambient Humidity: up to 85% RH .

Protection Class: IP20 .

Safety Features: Automatic overload protection; smooth motor start; emergency stop safety switch; thermal fuse for overload protection .

3. PHYSICAL & OPERATIONAL PROPERTIES

Construction: Compact benchtop design with lightweight (1.7 kg) drive unit; ergonomic grip for handheld operation; optional H-600 stand for hands-free, stationary use .

Dispersing Shafts: Interchangeable shafts with tool-free attachment; fully autoclavable 316L stainless steel construction; PTFE seal rings for chemical resistance; available in two configurations: DS-500/1 for solid-liquid mixing, DS-500/2 for emulsification .

Principle: Rotor-stator mechanism where samples are drawn into the core of the homogenizer by a rotor turning at high speed (10,000-30,000 rpm), then forced through narrow slits in the stator where high shear forces cause rapid tissue disruption, emulsification, and cell lysis .

Control: 6-stage rotary speed dial with positions for precise adjustment of homogenization intensity .

Operation Modes: Handheld mode for manual operation; H-600 stand mode for hands-free, stationary operation .

Safety Features: Automatic overload protection extends motor lifespan ; smooth motor start prevents splashing and sample loss ; emergency stop safety switch for immediate shutdown .

Portability: Compact (75 × 75 × 280 mm) and lightweight (1.7 kg) for easy transport between workstations and benchtop storage.

Maintenance: Dispersing shafts are easily disassembled without specialized tools for cleaning and sterilization; AC carbon brush motor requires periodic brush replacement .

4. SAFETY & COMPLIANCE ATTRIBUTES

Regulatory Status: General laboratory equipment for research and in vitro diagnostic use; meets applicable laboratory safety standards .

Safety Features: IP20 protection rating provides protection against solid objects >12mm; automatic overload protection mechanism maximizes motor working life; smooth motor start prevents splashing and sample loss; emergency stop safety switch for immediate shutdown .

Electrical Safety: Universal voltage (100-240V, 50/60Hz) for international use; 500W power consumption; earthed power connection recommended; thermal fuse for overload protection .

Noise Control: ≤79 dB(A) operation level; insulated motor housing keeps motor noise to safe, approved level .

Material Safety: SS 316L stainless steel (corrosion-resistant, biocompatible, autoclavable); PTFE seals (chemically inert, biocompatible, autoclavable) .

Sterilization Compatibility: Dispersing shafts are fully autoclavable at 121°C for aseptic applications .

Certifications: CE certified; meets applicable safety standards .

5. STORAGE & HANDLING ATTRIBUTES

Storage: Store drive unit on clean, dry benchtop or in designated storage area; dispersing shafts should be cleaned and dried before storage; H-600 stand provides convenient storage for drive unit and shaft during idle periods .

Inspection: Inspect dispersing shafts for damage (bent shafts, worn PTFE seals, corrosion) before each use; verify shaft is securely attached to drive unit; inspect power cord for damage before each use; check stand stability before mounting drive unit .

Shaft Selection: Use High Shear Homogenize/1 shaft for solid-liquid mixing, tissue homogenization, and general dispersion; use High Shear Homogenize/2 shaft for emulsification, cream preparation, and oil-water mixing .

Speed Selection: Use lower speeds (position 1-2) for soft tissues and cell suspensions; use medium speeds (position 3-4) for muscle, liver, and organ tissues; use higher speeds (position 5-6) for tough tissues, fibrous materials, high-viscosity samples, and emulsion preparation .

Aseptic Technique: For sterile applications, use autoclaved dispersing shafts and perform homogenization in biosafety cabinet; avoid aerosol generation.

Stand Use: For hands-free operation, mount drive unit on H-600 stand; secure stand on stable benchtop; clamp sample container in position; lower drive unit so shaft is properly immersed; operate with both hands free .

Spill Management: If sample spills onto drive unit, disconnect power immediately, clean thoroughly with appropriate disinfectant, allow to dry before reuse.