Horizontal Electrophoresis Tank (DL-SUB01)

Horizontal Electrophoresis Tank (DL-SUB01)

PRIMARY CLINICAL & DIAGNOSTIC USES

1. PCR Product Confirmation for Infectious Disease Testing

• Primary Use: Provides a compact horizontal electrophoresis tank designed for rapid separation and visualization of DNA fragments, enabling confirmation of PCR amplification products for infectious disease diagnosis .
• How it helps: For the molecular biologist and clinical laboratory scientist, the DL-SUB01 delivers reliable separation of PCR products (e.g., COVID-19, influenza, hepatitis, HIV) by size—enabling visual confirmation of target amplification and assessment of product purity. For the patient undergoing molecular diagnostic testing, accurate PCR product confirmation ensures reliable test results that guide appropriate treatment decisions.

2. Restriction Fragment Analysis for Genetic Screening

• Primary Use: Supports separation of restriction enzyme-digested DNA fragments for restriction fragment length polymorphism (RFLP) analysis, genetic fingerprinting, and mutation detection .
• How it helps: For the molecular geneticist, the DL-SUB01 facilitates detection of genetic mutations and polymorphisms by separating restriction fragments according to size—enabling diagnosis of inherited disorders (e.g., sickle cell disease, cystic fibrosis) and genetic screening applications . For the patient undergoing genetic testing, accurate fragment separation supports definitive diagnosis and informs clinical management.

3. Nucleic Acid Quality Assessment for Molecular Diagnostics

• Primary Use: Used for rapid assessment of DNA and RNA integrity, purity, and concentration before downstream molecular applications such as PCR, sequencing, and hybridization assays .
• How it helps: For the clinical laboratory scientist, the DL-SUB01 provides visual confirmation of nucleic acid quality—enabling detection of degradation, contamination, or concentration issues that could compromise diagnostic test results. For the patient, proper sample quality assessment ensures that only high-quality specimens proceed to diagnostic testing, reducing the risk of false-negative or false-positive results.

4. High-Throughput Sample Processing for Clinical Laboratories

• Primary Use: Features interchangeable gel trays (60 × 60 mm and 120 × 60 mm) and multiple comb configurations (1-2 wells and 5-10 wells), allowing flexible sample loading from 5 to 2500 bp separation ranges .
• How it helps: For the laboratory manager, the DL-SUB01’s interchangeable tray and comb system allows rapid adaptation to varying sample volumes and throughput demands—optimizing workflow efficiency for busy molecular diagnostics labs. For the patient, flexible throughput capacity reduces turnaround time for diagnostic results across different test volumes.

SECONDARY & SUPPORTIVE USES

1. RNA Denaturing Gel Electrophoresis: Used for formaldehyde-agarose gel electrophoresis for assessing RNA integrity and purity (28S/18S ratio) in molecular diagnostics.

2. Multiplex PCR Product Resolution: Supports separation of multiple PCR amplicons of different sizes in a single lane for multiplex pathogen detection (e.g., respiratory virus panels) .

3. Microbial Pathogen Identification: Used for PCR product confirmation in bacterial, viral, and fungal identification workflows in clinical microbiology.

4. DNA Fragment Size Determination: Supports molecular weight determination of DNA fragments using DNA ladders and size markers.

5. Gel Extraction and Purification: Used for separation and visualization of target DNA fragments before gel extraction for downstream applications (e.g., sequencing, cloning).

6. Southern Blotting Sample Preparation: Provides DNA separation for subsequent transfer to membranes for hybridization-based detection.

7. PFGE Sample Confirmation: Used for checking DNA quality before pulsed-field gel electrophoresis (PFGE) for bacterial typing in outbreak investigations.

8. Blood Bank and Transfusion Medicine: Supports DNA-based blood group genotyping and donor screening for blood-borne pathogens.

9. Veterinary Diagnostic Laboratory: Used for PCR product confirmation and nucleic acid analysis for animal health testing.

10. Food Safety and Quality Testing: Supports GMO detection, foodborne pathogen identification, and food authenticity testing.

11. Environmental Microbiology Testing: Used for detection of microbial pathogens in water, soil, and environmental samples by PCR and electrophoresis.

12. Research and Academic Laboratories: Provides reliable electrophoresis for DNA fragment analysis in molecular biology research.

13. Educational and Training Laboratories: Supports teaching of PCR and electrophoresis techniques in medical and graduate training programs.