Pro Thermo Control (HC110)

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The Pro Thermo Control (HC110) is a programmable digital dry bath with both heating and cooling capabilities, designed for precise temperature-controlled sample preparation in clinical diagnostic, molecular biology, and research laboratories . With a temperature range from -5°C to 110°C (heating to 110°C, cooling to 25°C below room temperature) and temperature control accuracy of ±0.5°C, this compact benchtop unit provides consistent, uniform heating and cooling for a wide range of diagnostic and research applications .
The HC110-Pro features a microprocessor-controlled system with TFT display for real-time temperature and time monitoring, programmable memory supporting up to 9 custom temperature control programs, and rapid heating (5.5°C/min) and controlled cooling (2.5°C/min from 100°C to room temperature) capabilities . The magnetic adsorption technology allows tool-free, secure mounting of interchangeable aluminum heating blocks compatible with various tube formats including 0.2mL PCR tubes, 0.5mL, 1.5mL, 2mL, 5mL, 15mL, 50mL centrifuge tubes, and microplates . The included block lid provides heat preservation, temperature stability, and contamination prevention .
For the clinical laboratory scientist and molecular biologist, the HC110-Pro supports DNA denaturation for PCR preparation and nucleic acid amplification, enzyme-substrate reactions for biochemical tests and clinical chemistry, serum inactivation for immunoassays and serological testing, protein denaturation for Western blotting and purification, and restriction enzyme heat inactivation . The active cooling capability enables rapid cooling of samples after high-temperature processing, preserving heat-sensitive DNA, RNA, enzymes, and proteins for downstream molecular diagnostic workflows .
Safety features include over-temperature protection (150°C safety cut-off) , built-in temperature calibration function for long-term accuracy , and magnetic block recognition . For the patient undergoing diagnostic testing for infectious diseases, genetic conditions, or oncology biomarkers, the HC110-Pro’s precise temperature control (±0.5°C accuracy) and combined heating/cooling capability ensure reliable enzyme reaction conditions, consistent DNA denaturation, and accurate sample preparation—supporting reliable test results that guide appropriate treatment decisions across clinical chemistry, molecular diagnostics, and research applications .
Description

Pro Thermo Control (HC110)

PRIMARY CLINICAL & DIAGNOSTIC USES

1. Dual Heating and Cooling for Molecular Biology Sample Preparation
  • Primary Use: Provides a programmable thermal control system with both heating and cooling capabilities (temperature range -5°C to 110°C), enabling precise temperature control for a wide range of molecular biology and clinical diagnostic applications .
  • How it helps: For the molecular biologist and clinical laboratory scientist, the HC110-Pro delivers precise temperature control (accuracy ±0.5°C at 20-45°C) with rapid heating (5.5°C/min) and controlled cooling (2.5°C/min from 100°C to room temperature, 0.5°C/min below room temperature)—eliminating the need for separate heating and cooling devices and reducing sample handling steps . For the patient, consolidated equipment reduces processing time and minimizes the risk of sample degradation between different temperature protocols.
2. Enzyme Reaction and Biochemical Test Incubation
  • Primary Use: Used for precise incubation of enzyme-substrate reactions, biochemical assays, and clinical chemistry tests requiring stable, controlled temperatures from -5°C to 110°C .
  • How it helps: For the clinical chemist, the HC110-Pro’s exceptional temperature uniformity (±0.5°C at 37°C) ensures consistent conditions for enzymatic assays—critical for accurate liver function tests (ALT, AST), cardiac biomarkers, and other enzyme-based diagnostic tests . For the patient, reliable enzymatic assay results enable accurate diagnosis of myocardial infarction, hepatitis, and other conditions requiring enzyme level monitoring.
3. DNA Denaturation and Nucleic Acid Amplification
  • Primary Use: Provides controlled heating for DNA denaturation steps in PCR preparation, nucleic acid amplification protocols, and molecular diagnostic workflows requiring precise temperature control up to 110°C .
  • How it helps: For the molecular biologist, the HC110-Pro’s precise temperature control and rapid heating rate (5.5°C/min) ensures consistent denaturation of double-stranded DNA—critical for PCR, sequencing, and hybridization-based assays . The programmable memory supports up to 9 custom temperature control programs, allowing storage of validated protocols for routine diagnostic workflows . For the patient undergoing genetic testing, reliable denaturation supports accurate PCR results and appropriate treatment decisions.
4. Rapid Cooling for Temperature-Sensitive Sample Preservation
  • Primary Use: Active cooling capability (down to -5°C and 25°C below room temperature) enables rapid cooling of samples after high-temperature processing, preserving heat-sensitive analytes and preventing degradation .
  • How it helps: For the clinical laboratory scientist, the HC110-Pro’s controlled cooling rates (2.5°C/min from 100°C to room temperature) allow rapid temperature reduction after denaturation or inactivation steps—protecting temperature-sensitive DNA, RNA, enzymes, and proteins from thermal degradation. For the patient, rapid cooling preserves sample integrity, reducing the need for repeat specimen collection and ensuring accurate test results.

SECONDARY & SUPPORTIVE USES

1. Serum Inactivation and Complement Fixation: Used for serum inactivation protocols (typically at 56°C) and complement fixation tests in diagnostic immunology.
2. Protein Denaturation and Purification: Used for protein denaturation steps in Western blotting, SDS-PAGE, and protein purification workflows .
3. Restriction Enzyme Heat Inactivation: Used for complete inactivation of restriction enzymes after DNA digestion to prevent interference with subsequent ligation or amplification steps .
4. ELISA and Immunoassay Incubation: Provides precise temperature control for enzyme-linked immunosorbent assay (ELISA) incubation steps in infectious disease and autoimmune testing .
5. Nucleic Acid Extraction and Purification: Supports heating and cooling steps in spin column-based DNA/RNA extraction protocols for molecular diagnostics.
6. Lipid and Cholesterol Analysis: Used for warming samples and reagents in lipid profiling and cholesterol fractionation protocols.
7. Endocrine and Hormone Assay Preparation: Supports temperature-controlled incubation for thyroid function tests, reproductive hormone panels, and endocrine assays.
8. Coagulation Testing Sample Warming: Used for warming plasma samples and reagents for PT (Prothrombin Time) and PTT (Partial Thromboplastin Time) coagulation studies .
9. Therapeutic Drug Monitoring: Used for warming samples and reagents in therapeutic drug monitoring and toxicology screening .
10. Blood Bank and Transfusion Medicine: Supports temperature-controlled processing of blood components and compatibility testing samples .
11. Histology and Pathology Tissue Processing: Used for warming embedding media and processing solutions in histology laboratories .
12. Microbiology Culture Media Warming: Warms culture media to specified temperatures before inoculation in clinical microbiology workflows.
13. Pharmaceutical Quality Control: Used for stability testing and sample preparation in pharmaceutical QC laboratories.
14. Research and Academic Laboratories: Supports general laboratory incubation needs requiring both heating and cooling capabilities.
15. Veterinary Diagnostic Laboratory: Supports clinical chemistry, molecular biology, and serology workflows for animal health testing.
KEY PRODUCT FEATURES

1. BASIC IDENTIFICATION ATTRIBUTES

  • Device Type: A programmable digital thermo control (dry bath) with both heating and cooling capabilities (range -5°C to 110°C), TFT display, and magnetic block mounting system, designed for clinical diagnostic and molecular biology applications .
  • Designation: HC110-Pro Thermo Control, Digital Thermo Control, Heating and Cooling Dry Bath, Thermostatic Metal Bath, DLAB HC110-Pro, Magnetic Thermo Control .
  • Key Components:
    • Heating/Cooling Block: Interchangeable aluminum blocks with magnetic adsorption technology for tool-free mounting .
    • Microprocessor Controller: Regulates temperature with automatic feedback for precise control from -5°C to 110°C .
    • TFT Display: Full-color TFT screen for real-time monitoring of temperature and time settings .
    • Control Interface: User-friendly interface with programmable memory (9 programs) .
    • Block Lid: Insulated block lid for heat preservation, temperature stability, and contamination prevention .
    • Magnetic Mounting System: Magnet adhesion technology for quick, tool-free block interchange .

2. TECHNICAL & PERFORMANCE PROPERTIES

  • Temperature Setting Range: -5°C to 110°C .
  • Temperature Control Range: Heating: room temperature to 110°C; Cooling: room temperature to 25°C below room temperature .
  • Temperature Control Accuracy: ±0.5°C (at 20-45°C) .
  • Temperature Uniformity: ±0.5°C (max.) .
  • Maximum Heating Rate: 5.5°C/min .
  • Maximum Cooling Rate: 2.5°C/min (100°C to room temperature); 0.5°C/min (below room temperature) .
  • Time Setting Range: 0 minutes to 99 hours 59 minutes .
  • Program Memory: 9 program storage capacity .
  • Display: TFT (full-color) .
  • Overheating Protection: 150°C safety cutoff .
  • Functions: Heating and cooling .
  • Power: 180W - 200W .
  • Voltage/Frequency: 110/220V, 50/60Hz (universal voltage) .
  • Dimensions (W × D × H): 200 × 235 × 120 mm .
  • Weight: 7.3 kg .
  • Block Mounting: Magnetic adsorption technology, tool-free .
  • Permissible Ambient Temperature: 10-40°C .
  • Permissible Ambient Humidity: <80% RH .

3. PHYSICAL & OPERATIONAL PROPERTIES

  • Construction: Compact benchtop housing (200 × 235 × 120 mm) with durable components for heating and cooling operation.
  • Mounting System: Magnetic block mounting with magnet adhesion technology for tool-free, quick interchange of heating blocks .
  • Control System: Microprocessor-controlled with programmable memory (9 programs) and TFT display for real-time monitoring .
  • Program Features: Supports program editing and storage; built-in temperature calibration function .
  • Block Lid: Included block lid for heat preservation, temperature stability, and contamination prevention .
  • Operation Modes: Timed operation (0-99h59min) and continuous operation mode.
  • Block Compatibility: Accepts various interchangeable aluminum blocks for tube formats including 0.2mL PCR tubes, 0.5mL, 1.5mL, 2mL, 5mL, 15mL, 50mL centrifuge tubes, and microplates .
  • Cooling Function: Active cooling capability maintains temperatures below ambient; supports pre-cooling protocols .
  • Calibration: Built-in temperature calibration function for long-term accuracy .
  • Portability: Lightweight (7.3 kg) with compact footprint for benchtop use.

4. SAFETY & COMPLIANCE ATTRIBUTES

  • Regulatory Status: Class I medical device for clinical diagnostic use; complies with In Vitro Diagnostic (IVD) medical equipment requirements .
  • Safety Features: Over-temperature protection (150°C safety cut-off), block lid for contamination prevention, overheating protection with automatic shutdown .
  • Electrical Safety: Universal voltage (110/220V, 50/60Hz); over-current protection .
  • GLP Compliance: Programmable protocols support GLP documentation; TFT display for real-time monitoring .
  • Temperature Calibration: Built-in self-calibration function ensures long-term accuracy .
  • Block Recognition: Magnetic adsorption technology with automatic block recognition .

5. STORAGE & HANDLING ATTRIBUTES

  • Storage: Store on clean, dry benchtop; ensure adequate clearance for ventilation; ambient temperature 10-40°C, relative humidity <80% RH .
  • Cleaning: Wipe exterior with soft, damp cloth using neutral detergent; 70% ethanol solution may be used for surface sterilization; magnetic mounting system allows tool-free block removal for easy cleaning .
  • Block Maintenance: Remove and clean aluminum heating blocks with mild detergent; dry thoroughly before reinstallation; blocks feature magnetic adhesion for secure mounting .
  • Inspection: Inspect block contacts for residue or damage before each use; clean if needed.
  • Lid Use: Always use block lid during operation to maintain temperature stability and prevent contamination .
  • Calibration: Perform periodic temperature calibration per manufacturer guidelines; built-in calibration function available .
  • Power Cord: Inspect power cord for damage before each use.

6. LABORATORY & CLINICAL APPLICATIONS

  • Primary Application: Precise temperature-controlled heating and cooling for molecular biology (DNA denaturation, PCR preparation), clinical chemistry (enzyme reactions, biochemical tests), and diagnostic workflows requiring temperatures from -5°C to 110°C .
  • Clinical Role: Essential sample preparation and incubation equipment in clinical diagnostic laboratories, hospital molecular diagnostics labs, blood banks, pathology departments, research laboratories, and pharmaceutical QC facilities requiring both heating and cooling capabilities .
SAFETY HANDLING PRECAUTIONS

1. SAFETY PRECAUTIONS

  • Temperature Setting: Do not exceed recommended temperatures for specific sample types; excessive heat may denature proteins or degrade analytes; use caution when setting temperatures above 95°C .
  • Block Installation: Ensure heating block is properly seated with magnetic mounting system before operation; magnetic adsorption provides secure attachment without tools .
  • Temperature Verification: Allow unit to reach set temperature before loading temperature-sensitive samples; verify temperature stability before use; pre-cooling function available for cooled protocols .
  • Lid Use: Always use block lid during operation to maintain temperature stability and prevent contamination .
  • Hot Surface Warning: Block and lid may become hot during heating operations above 50°C; use caution when handling .
  • Cold Surface Warning: Block may become cold during cooling operations below ambient temperature; use appropriate handling precautions .
  • Cleaning: Clean spills immediately; disinfect heating block if biological materials are involved; allow block to cool or warm to safe temperature before removal.
  • Placement: Place on firm, flat, level, heat-resistant surface; ensure adequate clearance around unit for ventilation .
  • Training: Only trained laboratory personnel should operate the HC110-Pro for clinical diagnostic applications.

2. FIRST AID MEASURES

  • Burn/Scald: If hot heating block or surface contacts skin during heating operation, cool affected area immediately with cool running water for at least 15 minutes; seek medical attention for severe burns .
  • Cold Injury: If cold surface contacts skin during cooling operation, warm affected area gradually with lukewarm water; seek medical attention for prolonged exposure.
  • Sample Spillage: If biological sample spills into unit, disconnect power, allow unit to return to safe temperature, disinfect area immediately with 70% ethanol or appropriate disinfectant.
  • Electrical Malfunction: If unit shows signs of electrical malfunction, disconnect power immediately; do not attempt to operate; contact service personnel.
  • Calibration Verification: If test results are inconsistent, perform temperature calibration using built-in calibration function before proceeding with diagnostic testing .

3. FIRE FIGHTING MEASURES

  • Flammability: Plastic housing and electrical components may burn.
  • Extinguishing Media: Use carbon dioxide or dry chemical extinguisher for electrical fires.
  • Fire Response: Unplug unit immediately; do not use water on electrical fire.