Pro Thermo Mix (HCM100)

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The Pro Thermo Mix (HCM100) is a programmable digital thermomixer (thermal mixer) that integrates heating, cooling, and orbital mixing functions in a single compact benchtop instrument, designed for comprehensive sample preparation in molecular diagnostics, clinical chemistry, and research laboratories . With a temperature range from 0°C to 100°C (heating to 100°C, cooling to 15°C below room temperature), temperature control accuracy of ±0.5°C, and orbital mixing speed range of 200-1500 rpm (3mm orbit), this thermomixer provides precise, uniform temperature control and consistent sample agitation for a wide range of diagnostic and research applications .

The HCM100-Pro features a microprocessor-controlled system with full-color TFT display for real-time monitoring of temperature, time, and mixing speed, programmable memory supporting up to 9 custom programs, rapid heating (5.5°C/min) and controlled cooling (5°C/min from 100°C to ambient, 0.5°C/min below ambient) capabilities, and automatic block recognition . The magnetic adsorption technology allows tool-free, secure mounting of interchangeable aluminum heating blocks compatible with various tube formats including 0.2mL PCR tubes, 0.5mL, 1.5mL, 2mL, 5mL, 15mL, 50mL centrifuge tubes, and microplates . The included block lid provides heat preservation, temperature stability, and contamination prevention .

For the molecular biologist and clinical laboratory scientist, the HCM100-Pro supports nucleic acid extraction and purification (DNA/RNA) protocols requiring controlled temperature incubation and mixing, enzymatic reactions (restriction enzyme digestions, ligations, PCR preparation), protein denaturation for Western blotting and SDS-PAGE, solid phase extraction (SPE) applications, gene synthesis and purification, and bacterial culture preparation . The active cooling capability (to 15°C below ambient) enables rapid cooling of samples after high-temperature processing, preserving heat-sensitive DNA, RNA, enzymes, and proteins for downstream molecular diagnostic workflows .

Safety features include over-temperature protection (150°C safety cut-off) , built-in temperature calibration function for long-term accuracy , automatic block recognition , and cTUVus and CE safety certifications . For the patient undergoing diagnostic testing for infectious diseases, genetic conditions, or oncology biomarkers, the HCM100-Pro’s precise temperature control (±0.5°C accuracy) and integrated heating/cooling/mixing capabilities ensure reliable nucleic acid extraction, consistent enzymatic reaction conditions, and accurate sample preparation—supporting reliable test results that guide appropriate treatment decisions across clinical chemistry, molecular diagnostics, and research applications .

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Categories: LABORATORY EQUIPMENT AND SUPPLIES, Incubators and Ovens Tags: Clinical Laboratory Equipment, Digital Thermo Mixer, DLAB HCM100-Pro, Enzymatic Reaction, HCM100-Pro Thermo Mix, Heating and Cooling Mixer, Molecular Diagnostics, Nucleic Acid Extraction, PCR Preparation, Protein Denaturation, Thermal Mixer, Thermomixer

Description

Pro Thermo Mix (HCM100)

PRIMARY CLINICAL & DIAGNOSTIC USES

1. Integrated Heating, Cooling, and Mixing for Molecular Diagnostics

Primary Use: Provides a programmable digital thermo mixer (thermomixer) combining heating, cooling, and orbital mixing functions (temperature range 0°C to 100°C, mixing speed 200-1500 rpm) for comprehensive sample preparation in molecular diagnostics .
How it helps: For the molecular biologist and clinical laboratory scientist, the HCM100-Pro integrates three essential sample preparation functions into a single benchtop instrument—eliminating the need for separate devices, reducing sample handling steps, and minimizing contamination risk. For the patient, consolidated equipment reduces processing time and ensures consistent sample treatment across multiple diagnostic workflows.

2. Nucleic Acid Extraction and Purification

Primary Use: Used for DNA and RNA extraction protocols requiring controlled temperature incubation (lysis steps, protein digestion, elution) combined with orbital mixing for efficient sample homogenization .
How it helps: For the molecular diagnostics technologist, the HCM100-Pro’s precise temperature control (±0.5°C) combined with adjustable mixing (200-1500 rpm) ensures efficient cell lysis, complete protein digestion, and optimal nucleic acid binding and elution from spin columns. For the patient undergoing genetic testing, efficient nucleic acid extraction supports accurate PCR and sequencing results, enabling reliable diagnosis of genetic disorders, infectious diseases, and cancer biomarkers.

3. Enzymatic Reaction Incubation with Agitation

Primary Use: Provides controlled temperature incubation (0°C to 100°C) with orbital mixing (3mm orbit) for enzyme-substrate reactions, restriction enzyme digestions, ligations, and other biochemical assays requiring uniform temperature and agitation .
How it helps: For the clinical chemist and molecular biologist, the HCM100-Pro’s uniform temperature distribution (±0.5°C at 20-45°C) combined with consistent orbital mixing ensures optimal reaction kinetics and complete enzymatic activity—critical for accurate liver function tests (ALT, AST), cardiac biomarkers, restriction mapping, and cloning workflows. For the patient, reliable enzymatic assay results enable accurate diagnosis of myocardial infarction, hepatitis, and other conditions requiring enzyme level monitoring.

4. Protein Denaturation and Sample Preparation

Primary Use: Used for protein denaturation steps in Western blotting, SDS-PAGE, and immunoassay sample preparation, with programmable protocols for consistent heating and mixing .
How it helps: For the immunology and protein science specialist, the HCM100-Pro’s programmable memory (up to 9 programs) allows storage of validated denaturation protocols, ensuring consistent sample treatment across multiple runs and operators. For the patient undergoing autoimmune or protein-based diagnostic testing, consistent denaturation ensures accurate detection of antibodies and proteins, supporting reliable diagnosis of autoimmune disorders, allergies, and protein abnormalities.

SECONDARY & SUPPORTIVE USES

1. Solid Phase Extraction (SPE) Applications: Used for temperature-controlled elution and incubation steps in SPE procedures, with mixing for improved extraction efficiency .

2. Oligonucleotide Synthesis and Deprotection: Supports deprotection steps and synthesis workflows requiring precise temperature control and mixing .

3. PCR and qPCR Sample Preparation: Used for PCR reaction set-up, including mixing of master mixes with templates and primers under controlled conditions.

4. Gene Synthesis and Purification: Supports gene synthesis workflows requiring precise temperature control for annealing, ligation, and purification steps .

5. Bacterial Growth and Culture Preparation: Provides controlled temperature incubation with mixing for bacterial culture preparation and growth monitoring .

6. Protein Precipitation and Purification: Used for protein precipitation steps in biochemical assays and protein purification workflows requiring mixing.

7. Lipid and Cholesterol Analysis Sample Preparation: Used for warming and mixing samples in lipid profiling and cholesterol fractionation protocols.

8. Immunoassay and ELISA Preparation: Supports ELISA and immunoassay sample preparation with controlled temperature and mixing for consistent results.

9. Antibody and Antigen Incubation: Provides temperature-controlled incubation with orbital mixing for antibody-antigen binding reactions.

10. Hemoglobin A1c and Diabetes Testing: Used in HbA1c sample preparation protocols requiring precise temperature control and mixing.

11. Therapeutic Drug Monitoring: Used for sample preparation in therapeutic drug monitoring and toxicology screening with controlled temperature and mixing.

12. Endocrine and Hormone Assay Preparation: Supports temperature-controlled incubation with mixing for thyroid function tests, reproductive hormone panels, and endocrine assays.

13. Cell Lysis and Homogenization: Used for cell lysis protocols in protein and nucleic acid extraction workflows.

14. Magnetic Bead-Based Assays: Used for mixing in magnetic bead-based separation protocols for nucleic acid and protein purification.

15. Research and Academic Laboratories: Supports general laboratory applications requiring simultaneous heating/cooling and mixing for diverse research protocols.

16. Programmable Multi-Step Protocols: Customizable user program setting with up to 9 program memory slots for complex sample preparation workflows .

17. Automatic Block Recognition: Unit automatically identifies installed heating block type for optimized temperature control .

18. Magnetic Block Mounting: Tool-free magnetic block interchange for rapid switching between different tube formats .

KEY PRODUCT FEATURES

1. BASIC IDENTIFICATION ATTRIBUTES

Device Type: A programmable digital thermo mixer (thermomixer) combining heating, cooling, and orbital mixing functions in a single benchtop instrument for comprehensive sample preparation in molecular diagnostics, clinical chemistry, and research laboratories .
Designation: HCM100-Pro Thermo Mix, Digital Thermo Mixer, Thermomixer, Heating & Cooling Mixer, DLAB HCM100-Pro, Thermal Mixer with Heating/Cooling/Mixing.
Key Components:
- Heating/Cooling Block: Interchangeable aluminum blocks with magnetic adsorption technology for tool-free mounting; supports various tube formats (0.2mL PCR, 0.5mL, 1.5mL, 2mL, 5mL, 15mL, 50mL, and microplates) .
- Microprocessor Controller: Regulates temperature and mixing speed with automatic feedback for precise control from 0°C to 100°C .
- TFT Display: Full-color TFT screen for real-time monitoring of temperature, time, and mixing speed .
- Control Interface: User-friendly interface with programmable memory (9 programs) .
- Block Lid: Insulated block lid for heat preservation, temperature stability, and contamination prevention .
- Magnetic Mounting System: Magnet adhesion technology for quick, tool-free block interchange .
- Automatic Block Recognition: Identifies installed heating block type for optimized temperature control .

2. TECHNICAL & PERFORMANCE PROPERTIES

Functions: Heating, cooling, and mixing (all three functions integrated) .
Temperature Range: Heating up to 100°C; Cooling up to 15°C below room temperature (or 0°C actual) .
Temperature Setting Range: 0°C to 100°C .
Temperature Control Accuracy: ±0.5°C (at 20-45°C) .
Temperature Uniformity: ±0.5°C (max.) .
Maximum Heating Rate: 5.5°C/min .
Maximum Cooling Rate: 5°C/min (100°C to room temperature); 0.5°C/min (below room temperature) .
Mixing Speed Range: 200-1500 rpm .
Mixing Orbit: 3mm (horizontal rotation) .
Time Setting Range: 0 minutes to 99 hours 30 minutes .
Program Memory: 9 program storage capacity .
Display: TFT (full-color) .
Overheating Protection: 150°C safety cut-off .
Block Mounting: Magnetic adsorption technology, tool-free .
Block Recognition: Automatic block identification .
Power: 200W .
Voltage/Frequency: 100-240V, 50/60Hz (universal voltage) .
Dimensions (W × D × H): 200 × 235 × 120 mm .
Weight: 7.3 kg .
Permissible Ambient Temperature: 10-40°C .
Permissible Ambient Humidity: <80% RH .
Certifications: cTUVus approved, CE marked .

3. PHYSICAL & OPERATIONAL PROPERTIES

Construction: Compact benchtop housing (200 × 235 × 120 mm) with durable components for combined heating, cooling, and mixing operation.
Mounting System: Magnetic block mounting with magnet adhesion technology for tool-free, quick interchange of heating blocks .
Control System: Microprocessor-controlled with programmable memory (9 programs) and TFT display for real-time monitoring of temperature, time, and speed .
Program Features: Supports program editing and storage; built-in temperature calibration function; automatic block recognition .
Block Lid: Included block lid for heat preservation, temperature stability, and contamination prevention .
Operation Modes: Timed operation (0-99h30min) and continuous operation mode.
Block Compatibility: Accepts various interchangeable aluminum blocks for tube formats including 0.2mL PCR tubes, 0.5mL, 1.5mL, 2mL, 5mL, 15mL, 50mL centrifuge tubes, and microplates .
Cooling Function: Active cooling capability maintains temperatures below ambient; supports pre-cooling protocols .
Mixing Function: Orbital mixing with 3mm orbit and adjustable speed (200-1500 rpm) for uniform sample agitation .
Calibration: Built-in temperature calibration function for long-term accuracy.
Portability: Lightweight (7.3 kg) with compact footprint for benchtop use.

4. SAFETY & COMPLIANCE ATTRIBUTES

Regulatory Status: Class I medical device for clinical diagnostic use; certified for laboratory applications.
Safety Certifications: cTUVus approved; CE marked .
Safety Features: Over-temperature protection (150°C safety cut-off) ; block lid for contamination prevention; overheating protection with automatic shutdown; magnetic block recognition.
Electrical Safety: Universal voltage (100-240V, 50/60Hz); over-current protection; 200W power consumption.
GLP Compliance: Programmable protocols support GLP documentation; TFT display for real-time monitoring; 9 program memory storage.
Temperature Calibration: Built-in self-calibration function ensures long-term accuracy; three-point temperature calibration available .
Block Recognition: Automatic block identification for optimized temperature control .

5. STORAGE & HANDLING ATTRIBUTES

Storage: Store on clean, dry benchtop; ensure adequate clearance for ventilation; ambient temperature 10-40°C, relative humidity <80% RH .
Cleaning: Wipe exterior with soft, damp cloth using neutral detergent; 70% ethanol solution may be used for surface sterilization; magnetic mounting system allows tool-free block removal for easy cleaning .
Block Maintenance: Remove and clean aluminum heating blocks with mild detergent; dry thoroughly before reinstallation; blocks feature magnetic adhesion for secure mounting .
Inspection: Inspect block contacts for residue or damage before each use; clean if needed.
Lid Use: Always use block lid during operation to maintain temperature stability and prevent contamination .
Calibration: Perform periodic temperature calibration per manufacturer guidelines; built-in calibration function available.
Power Cord: Inspect power cord for damage before each use.

6. LABORATORY & CLINICAL APPLICATIONS

Primary Application: Integrated sample preparation for molecular diagnostics (nucleic acid extraction, PCR preparation, enzymatic reactions), clinical chemistry (enzyme assays, protein analysis), and research applications requiring simultaneous temperature control and orbital mixing .
Clinical Role: Essential sample preparation instrument in clinical diagnostic laboratories, hospital molecular diagnostics labs, blood banks, pathology departments, research laboratories, and pharmaceutical QC facilities requiring combined heating, cooling, and mixing capabilities.

SAFETY HANDLING PRECAUTIONS

1. SAFETY PRECAUTIONS

Temperature Setting: Do not exceed recommended temperatures for specific sample types; excessive heat may denature proteins or degrade analytes; use caution when setting temperatures above 95°C.
Block Installation: Ensure heating block is properly seated with magnetic mounting system before operation; magnetic adsorption provides secure attachment without tools .
Temperature Verification: Allow unit to reach set temperature before loading temperature-sensitive samples; verify temperature stability before use; pre-cooling function available for cooled protocols.
Lid Use: Always use block lid during operation to maintain temperature stability and prevent contamination .
Hot Surface Warning: Block and lid may become hot during heating operations above 50°C; use caution when handling.
Cold Surface Warning: Block may become cold during cooling operations below ambient temperature; use appropriate handling precautions.
Mixing Speed: Start with lower mixing speeds (300-500 rpm) before increasing to higher speeds to prevent sample splashing.
Cleaning: Clean spills immediately; disinfect heating block if biological materials are involved; allow block to cool or warm to safe temperature before removal.
Placement: Place on firm, flat, level, heat-resistant surface; ensure adequate clearance around unit for ventilation.
Training: Only trained laboratory personnel should operate the HCM100-Pro for clinical diagnostic applications.

2. FIRST AID MEASURES

Burn/Scald: If hot heating block or surface contacts skin during heating operation, cool affected area immediately with cool running water for at least 15 minutes; seek medical attention for severe burns.
Cold Injury: If cold surface contacts skin during cooling operation, warm affected area gradually with lukewarm water; seek medical attention for prolonged exposure.
Sample Spillage: If biological sample spills into unit, disconnect power, allow unit to return to safe temperature, disinfect area immediately with 70% ethanol or appropriate disinfectant.
Electrical Malfunction: If unit shows signs of electrical malfunction, disconnect power immediately; do not attempt to operate; contact service personnel.
Calibration Verification: If test results are inconsistent, perform temperature calibration using built-in calibration function before proceeding with diagnostic testing .

3. FIRE FIGHTING MEASURES

Flammability: Plastic housing and electrical components may burn.
Extinguishing Media: Use carbon dioxide or dry chemical extinguisher for electrical fires.
Fire Response: Unplug unit immediately; do not use water on electrical fire.

Pro Thermo Mix (HCM100)

Pro Thermo Mix (HCM100)

PRIMARY CLINICAL & DIAGNOSTIC USES

1. Integrated Heating, Cooling, and Mixing for Molecular Diagnostics

Primary Use: Provides a programmable digital thermo mixer (thermomixer) combining heating, cooling, and orbital mixing functions (temperature range 0°C to 100°C, mixing speed 200-1500 rpm) for comprehensive sample preparation in molecular diagnostics .

2. Nucleic Acid Extraction and Purification

Primary Use: Used for DNA and RNA extraction protocols requiring controlled temperature incubation (lysis steps, protein digestion, elution) combined with orbital mixing for efficient sample homogenization .

3. Enzymatic Reaction Incubation with Agitation

Primary Use: Provides controlled temperature incubation (0°C to 100°C) with orbital mixing (3mm orbit) for enzyme-substrate reactions, restriction enzyme digestions, ligations, and other biochemical assays requiring uniform temperature and agitation .

4. Protein Denaturation and Sample Preparation

Primary Use: Used for protein denaturation steps in Western blotting, SDS-PAGE, and immunoassay sample preparation, with programmable protocols for consistent heating and mixing .

SECONDARY & SUPPORTIVE USES

1. Solid Phase Extraction (SPE) Applications: Used for temperature-controlled elution and incubation steps in SPE procedures, with mixing for improved extraction efficiency .

2. Oligonucleotide Synthesis and Deprotection: Supports deprotection steps and synthesis workflows requiring precise temperature control and mixing .

3. PCR and qPCR Sample Preparation: Used for PCR reaction set-up, including mixing of master mixes with templates and primers under controlled conditions.

4. Gene Synthesis and Purification: Supports gene synthesis workflows requiring precise temperature control for annealing, ligation, and purification steps .

5. Bacterial Growth and Culture Preparation: Provides controlled temperature incubation with mixing for bacterial culture preparation and growth monitoring .

6. Protein Precipitation and Purification: Used for protein precipitation steps in biochemical assays and protein purification workflows requiring mixing.

7. Lipid and Cholesterol Analysis Sample Preparation: Used for warming and mixing samples in lipid profiling and cholesterol fractionation protocols.

8. Immunoassay and ELISA Preparation: Supports ELISA and immunoassay sample preparation with controlled temperature and mixing for consistent results.

9. Antibody and Antigen Incubation: Provides temperature-controlled incubation with orbital mixing for antibody-antigen binding reactions.

10. Hemoglobin A1c and Diabetes Testing: Used in HbA1c sample preparation protocols requiring precise temperature control and mixing.

11. Therapeutic Drug Monitoring: Used for sample preparation in therapeutic drug monitoring and toxicology screening with controlled temperature and mixing.

12. Endocrine and Hormone Assay Preparation: Supports temperature-controlled incubation with mixing for thyroid function tests, reproductive hormone panels, and endocrine assays.

13. Cell Lysis and Homogenization: Used for cell lysis protocols in protein and nucleic acid extraction workflows.

14. Magnetic Bead-Based Assays: Used for mixing in magnetic bead-based separation protocols for nucleic acid and protein purification.

15. Research and Academic Laboratories: Supports general laboratory applications requiring simultaneous heating/cooling and mixing for diverse research protocols.

16. Programmable Multi-Step Protocols: Customizable user program setting with up to 9 program memory slots for complex sample preparation workflows .

17. Automatic Block Recognition: Unit automatically identifies installed heating block type for optimized temperature control .

18. Magnetic Block Mounting: Tool-free magnetic block interchange for rapid switching between different tube formats .

1. BASIC IDENTIFICATION ATTRIBUTES

Device Type: A programmable digital thermo mixer (thermomixer) combining heating, cooling, and orbital mixing functions in a single benchtop instrument for comprehensive sample preparation in molecular diagnostics, clinical chemistry, and research laboratories .

Designation: HCM100-Pro Thermo Mix, Digital Thermo Mixer, Thermomixer, Heating & Cooling Mixer, DLAB HCM100-Pro, Thermal Mixer with Heating/Cooling/Mixing.

Key Components:

Heating/Cooling Block: Interchangeable aluminum blocks with magnetic adsorption technology for tool-free mounting; supports various tube formats (0.2mL PCR, 0.5mL, 1.5mL, 2mL, 5mL, 15mL, 50mL, and microplates) .

Microprocessor Controller: Regulates temperature and mixing speed with automatic feedback for precise control from 0°C to 100°C .

TFT Display: Full-color TFT screen for real-time monitoring of temperature, time, and mixing speed .

Control Interface: User-friendly interface with programmable memory (9 programs) .

Block Lid: Insulated block lid for heat preservation, temperature stability, and contamination prevention .

Magnetic Mounting System: Magnet adhesion technology for quick, tool-free block interchange .

Automatic Block Recognition: Identifies installed heating block type for optimized temperature control .

2. TECHNICAL & PERFORMANCE PROPERTIES

Functions: Heating, cooling, and mixing (all three functions integrated) .

Temperature Range: Heating up to 100°C; Cooling up to 15°C below room temperature (or 0°C actual) .

Temperature Setting Range: 0°C to 100°C .

Temperature Control Accuracy: ±0.5°C (at 20-45°C) .

Temperature Uniformity: ±0.5°C (max.) .

Maximum Heating Rate: 5.5°C/min .

Maximum Cooling Rate: 5°C/min (100°C to room temperature); 0.5°C/min (below room temperature) .

Mixing Speed Range: 200-1500 rpm .

Mixing Orbit: 3mm (horizontal rotation) .

Time Setting Range: 0 minutes to 99 hours 30 minutes .

Program Memory: 9 program storage capacity .

Display: TFT (full-color) .

Overheating Protection: 150°C safety cut-off .

Block Mounting: Magnetic adsorption technology, tool-free .

Block Recognition: Automatic block identification .

Power: 200W .

Voltage/Frequency: 100-240V, 50/60Hz (universal voltage) .

Dimensions (W × D × H): 200 × 235 × 120 mm .

Weight: 7.3 kg .

Permissible Ambient Temperature: 10-40°C .

Permissible Ambient Humidity: <80% RH .

Certifications: cTUVus approved, CE marked .

3. PHYSICAL & OPERATIONAL PROPERTIES

Construction: Compact benchtop housing (200 × 235 × 120 mm) with durable components for combined heating, cooling, and mixing operation.

Mounting System: Magnetic block mounting with magnet adhesion technology for tool-free, quick interchange of heating blocks .

Control System: Microprocessor-controlled with programmable memory (9 programs) and TFT display for real-time monitoring of temperature, time, and speed .

Program Features: Supports program editing and storage; built-in temperature calibration function; automatic block recognition .

Block Lid: Included block lid for heat preservation, temperature stability, and contamination prevention .

Operation Modes: Timed operation (0-99h30min) and continuous operation mode.

Block Compatibility: Accepts various interchangeable aluminum blocks for tube formats including 0.2mL PCR tubes, 0.5mL, 1.5mL, 2mL, 5mL, 15mL, 50mL centrifuge tubes, and microplates .

Cooling Function: Active cooling capability maintains temperatures below ambient; supports pre-cooling protocols .

Mixing Function: Orbital mixing with 3mm orbit and adjustable speed (200-1500 rpm) for uniform sample agitation .

Calibration: Built-in temperature calibration function for long-term accuracy.

Portability: Lightweight (7.3 kg) with compact footprint for benchtop use.

4. SAFETY & COMPLIANCE ATTRIBUTES

Regulatory Status: Class I medical device for clinical diagnostic use; certified for laboratory applications.

Safety Certifications: cTUVus approved; CE marked .

Safety Features: Over-temperature protection (150°C safety cut-off) ; block lid for contamination prevention; overheating protection with automatic shutdown; magnetic block recognition.